Review Article

Econ. Environ. Geol. 2015; 48(3): 241-246

Published online June 30, 2015

© THE KOREAN SOCIETY OF ECONOMIC AND ENVIRONMENTAL GEOLOGY

Overview of Helicobacter pylori and Treatment Options

Young Goo Song*

Division of Infectious Diseases, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Correspondence to : IMFELL@yuhs.ac

Received: June 23, 2015; Accepted: June 28, 2015

Abstract

Helicobacter pylori is an important transmissible human pathogen found on the luminal surface of the gastric epithelium. The organism can persist in the stomach indefinitely and causes gastroduodenal inflammation that may proceed to atrophic gastritis, peptic ulcer, gastric MALT lymphoma, and gastric cancer. Standard triple therapy which consists of proton pump inhibitor (PPI) plus two antibiotics (amoxicillin and clarithromycin) is now generally used in Korea, however, eradication rates of H. pylori has been decreasing due to increasing antibiotic resistance. In this review, current second-line treatment regimens, difficult problems on treatment, necessity of local target therapy, applicability of clay minerals as a drug delivery system (DDS), and a new therapeutic strategy and its study plans will be discussed.

Keywords Helicobacter pylori, amoxicillin, clarithromycin, local target therapy, drug delivery system (DDS), clay minerals

Article

Review Article

Econ. Environ. Geol. 2015; 48(3): 241-246

Published online June 30, 2015

Copyright © THE KOREAN SOCIETY OF ECONOMIC AND ENVIRONMENTAL GEOLOGY.

Overview of Helicobacter pylori and Treatment Options

Young Goo Song*

Division of Infectious Diseases, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Correspondence to:IMFELL@yuhs.ac

Received: June 23, 2015; Accepted: June 28, 2015

Abstract

Helicobacter pylori is an important transmissible human pathogen found on the luminal surface of the gastric epithelium. The organism can persist in the stomach indefinitely and causes gastroduodenal inflammation that may proceed to atrophic gastritis, peptic ulcer, gastric MALT lymphoma, and gastric cancer. Standard triple therapy which consists of proton pump inhibitor (PPI) plus two antibiotics (amoxicillin and clarithromycin) is now generally used in Korea, however, eradication rates of H. pylori has been decreasing due to increasing antibiotic resistance. In this review, current second-line treatment regimens, difficult problems on treatment, necessity of local target therapy, applicability of clay minerals as a drug delivery system (DDS), and a new therapeutic strategy and its study plans will be discussed.

Keywords Helicobacter pylori, amoxicillin, clarithromycin, local target therapy, drug delivery system (DDS), clay minerals

    KSEEG
    Apr 30, 2024 Vol.57 No.2, pp. 107~280

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